1. The shows first title was "Complications."
2. The show is set in Chicago.
3. Ellen Pampeo who plays Dr. Meredith Grey is the only actor to appear in every episode of the show.
4. The Grey's doctors are all smokers.
1. Fact - It was changed prior to the first show going on the air.
2. Fake - It is set in Seattle. Chicago was considered but because competing show "ER" was set there, Seattle was chosen.
3. Fact - Though to be fair Patrick Dempsey appeared in every episode up until his character was killed off.
4. Fact - Especially Meredith.